Amitriptyline induced Acute Dyskinesia

Acute polyradiculoneuropathy after amitriptyline overdose.

A 53 year. old depressive woman had been taking' amitriptyline 75 mg and lorazepam 2-5 mg daily in January 1984. At the beginning of February she took soluble amitriptyline 800 mg in a suicide. attempt. She became comatose, with generalised seizures, mydriasis, and urinary retention; her muscle stretch reflexes were normal, blood pressure 90/50 mm Hg, body temperature 370C, and' pulse 100 beats...

Clozapine-induced Tardive Dyskinesia

Amitriptyline-induced supersensitivity of a central muscarinic mechanism: lithium blocks amitriptyline-induced supersensitivity.

Chronic treatment with amitriptyline produces dose-dependent super-sensitivity of a central muscarinic cholinergic mechanism involved in the regulation of core body temperature. The authors demonstrated that chronic treatment with lithium prevents the induction of this response. The potential clinical and theoretical significance of this finding is set forth.

Bright light blocks amitriptyline-induced cholinoceptor supersensitivity.

Introduction thal et al., 1984). This syndrome reportedly Seasonal affective disorder (SAD) is a synresponds to daily treatment with 2-6 hr of drome marked by recurrent depressions that bright artificial light (Lewy et al. 1982; Rogenerally occur in the fall or winter (Rosensenthal et al. 1984, 1986; James et al. 1985; Wehr et al. 1986). Neurobiological mechanisms accounting for the efficacy of...

Levodopa-induced dyskinesia and thalamotomy.

Levodopa-induced dyskinesia of the limbs in thirteen cases of Parkinsonism, which was choreic, ballistic or dystonic in type, was alleviated almost completely by stereotaxic surgery using a microelectrode technique for the ventralis oralis anterior and posterior nuclei of the thalamus, but much less by the ventralis intermedius nucleus. Control of levodopa-induced dyskinesias by thalamic lesion...